Search results for " molecular diversity"
Article
Simulating chromatography processes in the growing molecular diversity
The increasing complexity and diversity of development pipelines poses new challenges for product manufacturing. Mechanistic modeling can play a key role in overcoming these challenges as they…
Article
Navigating Molecular Diversity
Are you working with biomolecules beyond mAbs?
Read more here >>
Article
Quality by design for biotechnology products—part 1
A PhRMA Working Group's advice on applying QbD to biotech.
By Taruna Arora, Roger Greene, Jennifer Mercer, Paul Tsang, Meg Casais, Stuart Feldman, Jutta Look, Tony Lubiniecki, Joseph Mezzatesta,…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Newer classes of biotherapies will require innovations in processing technology.
By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…
Article
Top Process Development Trends for 2022 and a Look into 2023
More Hands-on Content, as the Industry Struggles to Keep Up with the Science of novel molecules
In lockstep with increasing molecular diversity, popular content on the Process Development Forum la…
Article
A Look at the Affinity Chromatography Landscape
Affinity chromatography for bispecific antibodies
Due to the molecular diversity of bispecific antibodies, a general purification platform is not available. A toolbox approach is needed, in which …
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Analytical exoglycosidases are transitioning from being largely academic tools to being s…
Article
Tackling Analytical Method Development for ADCs
Feb 01, 2015
By Cynthia Challener, PhD
BioPharm International
Volume 28, Issue 2
The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …
Article
Insights from process developers - top challenges in recombinant protein purification
This constantly evolving molecular diversity brings challenges in chromatography process development. In this article, we focus on the challenges in purifying recombinant proteins that lack affinity c…
Article
Process Development and Control for New Modalities
Increasing molecular diversity leads to more challenges in process development and control. Advancements in technology for manufacturing and online analytical monitoring have not caught up…